A system to build distributed multivariate models and manage disparate data sharing policies: implementation in the scalable national network for effectiveness research.

TitleA system to build distributed multivariate models and manage disparate data sharing policies: implementation in the scalable national network for effectiveness research.
Publication TypeJournal Article
Year of Publication2015
AuthorsMeeker, D, Jiang, X, Matheny, ME, Farcas, C, D'Arcy, M, Pearlman, L, Nookala, L, Day, ME, Kim, KK, Kim, H, Boxwala, A, El-Kareh, R, Kuo, GM, Resnic, FS, Kesselman, C, Ohno-Machado, L
JournalJ Am Med Inform Assoc
Volume22
Issue6
Pagination1187-95
Date Published2015 Nov
ISSN1527-974X
iDASH CategoryData Sharing
Abstract<p><b>BACKGROUND: </b>Centralized and federated models for sharing data in research networks currently exist. To build multivariate data analysis for centralized networks, transfer of patient-level data to a central computation resource is necessary. The authors implemented distributed multivariate models for federated networks in which patient-level data is kept at each site and data exchange policies are managed in a study-centric manner.</p><p><b>OBJECTIVE: </b>The objective was to implement infrastructure that supports the functionality of some existing research networks (e.g., cohort discovery, workflow management, and estimation of multivariate analytic models on centralized data) while adding additional important new features, such as algorithms for distributed iterative multivariate models, a graphical interface for multivariate model specification, synchronous and asynchronous response to network queries, investigator-initiated studies, and study-based control of staff, protocols, and data sharing policies.</p><p><b>MATERIALS AND METHODS: </b>Based on the requirements gathered from statisticians, administrators, and investigators from multiple institutions, the authors developed infrastructure and tools to support multisite comparative effectiveness studies using web services for multivariate statistical estimation in the SCANNER federated network.</p><p><b>RESULTS: </b>The authors implemented massively parallel (map-reduce) computation methods and a new policy management system to enable each study initiated by network participants to define the ways in which data may be processed, managed, queried, and shared. The authors illustrated the use of these systems among institutions with highly different policies and operating under different state laws.</p><p><b>DISCUSSION AND CONCLUSION: </b>Federated research networks need not limit distributed query functionality to count queries, cohort discovery, or independently estimated analytic models. Multivariate analyses can be efficiently and securely conducted without patient-level data transport, allowing institutions with strict local data storage requirements to participate in sophisticated analyses based on federated research networks.</p>
DOI10.1093/jamia/ocv017
Alternate JournalJ Am Med Inform Assoc
PubMed ID26142423
PubMed Central IDPMC4639714
Grant ListR01 HS019913 / HS / AHRQ HHS / United States
R01HS019913 / HS / AHRQ HHS / United States
U54HL108460 / HL / NHLBI NIH HHS / United States
UL1TR000100 / TR / NCATS NIH HHS / United States