Differentially private genome data dissemination through top-down specialization.

TitleDifferentially private genome data dissemination through top-down specialization.
Publication TypeJournal Article
Year of Publication2014
AuthorsWang, S, Mohammed, N, Chen, R
JournalBMC Med Inform Decis Mak
Volume14 Suppl 1
PaginationS2
Date Published2014 Dec 8
ISSN1472-6947
iDASH CategoryPrivacy Technology
Abstract<p>Advanced sequencing techniques make large genome data available at an unprecedented speed and reduced cost. Genome data sharing has the potential to facilitate significant medical breakthroughs. However, privacy concerns have impeded efficient genome data sharing. In this paper, we present a novel approach for disseminating genomic data while satisfying differential privacy. The proposed algorithm splits raw genome sequences into blocks, subdivides the blocks in a top-down fashion, and finally adds noise to counts to preserve privacy. The experimental results suggest that the proposed algorithm can retain certain data utility in terms of a high sensitivity.</p>
DOI10.1186/1472-6947-14-S1-S2
Alternate JournalBMC Med Inform Decis Mak
PubMed ID25521306
PubMed Central IDPMC4290801
Grant ListK99 HG008175 / HG / NHGRI NIH HHS / United States
K99HG008175 / HG / NHGRI NIH HHS / United States
R00LM011392 / LM / NLM NIH HHS / United States
R01 HG007078 / HG / NHGRI NIH HHS / United States
R01HG007078 / HG / NHGRI NIH HHS / United States
R21LM012060 / LM / NLM NIH HHS / United States
U54HL108460 / HL / NHLBI NIH HHS / United States
UL1TR000100 / TR / NCATS NIH HHS / United States