A community assessment of privacy preserving techniques for human genomes.

TitleA community assessment of privacy preserving techniques for human genomes.
Publication TypeJournal Article
Year of Publication2014
AuthorsJiang, X, Zhao, Y, Wang, X, Malin, B, Wang, S, Ohno-Machado, L, Tang, H
JournalBMC Med Inform Decis Mak
Volume14 Suppl 1
PaginationS1
Date Published2014
ISSN1472-6947
iDASH CategoryPrivacy Technology
Abstract<p>To answer the need for the rigorous protection of biomedical data, we organized the Critical Assessment of Data Privacy and Protection initiative as a community effort to evaluate privacy-preserving dissemination techniques for biomedical data. We focused on the challenge of sharing aggregate human genomic data (e.g., allele frequencies) in a way that preserves the privacy of the data donors, without undermining the utility of genome-wide association studies (GWAS) or impeding their dissemination. Specifically, we designed two problems for disseminating the raw data and the analysis outcome, respectively, based on publicly available data from HapMap and from the Personal Genome Project. A total of six teams participated in the challenges. The final results were presented at a workshop of the iDASH (integrating Data for Analysis, 'anonymization,' and SHaring) National Center for Biomedical Computing. We report the results of the challenge and our findings about the current genome privacy protection techniques.</p>
DOI10.1186/1472-6947-14-S1-S1
Alternate JournalBMC Med Inform Decis Mak
PubMed ID25521230
PubMed Central IDPMC4290799
Grant ListK99 HG008175 / HG / NHGRI NIH HHS / United States
K99HG008175 / HG / NHGRI NIH HHS / United States
R00 LM011392 / LM / NLM NIH HHS / United States
R00LM011392 / LM / NLM NIH HHS / United States
R01 HG007078 / HG / NHGRI NIH HHS / United States
R01HG007078 / HG / NHGRI NIH HHS / United States
R21 LM012060 / LM / NLM NIH HHS / United States
R21LM012060 / LM / NLM NIH HHS / United States
U54HL108460 / HL / NHLBI NIH HHS / United States
UL1TR000100 / TR / NCATS NIH HHS / United States